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B) Your blood is a solution with water and blood cells. Red blood cells contain a protein called hemoglobin. Normally, hemoglobin is hydrophilic. However, in a person with sickle cell anemia, the hemoglobin on the red blood cells forms long chains in an effort to avoid water. These chains clump together, which results in the sickle shape of the cells. (Sickle Cell Disease)

If Glutamic acid (GLU) is a polar, hydrophilic molecule, what would you suspect is different about Valine (VAL)?

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Vimal1

Answer:

You would suspect that Valine (VAL) is hydrophobic since glutamic acid is being replaced by Valine in sickle cell disease which makes the RBC now hydrophobic and causing them to clump together rather than freely roam the blood streams